Behind the hype, where it’s more than just a flu
July 4th, 2009So, the local swine flu news reporting is annoying you. It’s just a flu, you said. Unpleasant symptoms aside, it is relatively harmless, as proven by the lack of mortality locally at least, and only the news-believer would think it’ll kill you overnight.
But how much do you know about the flu? Besides your scientific understanding that flu is a virus that can’t be cured by antibiotics therefor you can’t cure flu, and also the scientific name H1N1, what else do you know?
The Ministry of Health has a legitimate reason to worry. Swine flu is a subtype of Influenzavirus A. Influenzavirus A causes influenza in birds and some mammals. Subtypes of Influenzavirus A are Bird flu, Human flu, Swine flu, Horse flu, Dog flu, and Cat flu.
Before we go to the histories, I would like to explain a bit on why H1N1 was called H1N1.
Influenza A virus strains are categorized according to two proteins found on the surface of the virus: hemagglutinin (H) and neuraminidase (N). All influenza A viruses contain hemagglutinin and neuraminidase, but the structure of these proteins differ from strain to strain due to rapid genetic mutation in the viral genome. Let’s say in a strain, there’s 4 hemagglutinin (H) and 1 neuraminidase (N) - it will be called H4N1.
So, H1N1 was called H1N1 because it had 1 hemagglutinin (H) and 1 neuraminidase (N) protein.
Now, let’s assume Influenza A as a race, like Chinese. Swine flu is a family under the Chinese race with the surname Chan. The two proteins will be the two DNA feature of Chinese - slanted eyes and yellowish skin. Some Chinese have more prominent slanted eyes feature, some are barely noticeable, hence the variants. Also, other features like height and hair types make each family tree in the Chinese race different.
A summary of previous paragraph’s assumption:
Influenza A = Chinese
Swine Flu = Chan family
proteins H and N = two specific DNA that determines a person’s feature
other compositions in the virus = other DNA in a person
As we reproduce (having a baby), the end result would be a mix of two different sets of DNA, the same concept of the process genetic drift that causes mutation in virus strains (besides the fact that viruses don’t have sex). Throw in other family names like Tan and Lee (Bird flu and Human flu), and you will have a more complicated pot of mixture.
Mutation of strains should never be taken lightly. In 1918, there was a flu pandemic commonly known as the Spanish flu, which was caused a unusually virulent and deadly H1N1 strain. 10% to 20% of those who were infected died, and 3% to 6% of the entire global population died.
To sum it up: H1N1 mutated in 1918, and killed many people.
It caused an unusual number of deaths because it may have caused a cytokine storm in the body. Cytokine storm, in layman’s term, is a situation where the number of immune cells got activated to fight the bad cells, are a lot higher than it should be, and the effect differs by where the immune cells are concentrating at. If it happens at your lungs, you get conditions similar to pneumonia - fluids build up in your lung and block off your airway. Kind of like drowning.
The recent epidemic of bird flu, also an Influenza A virus with H1N1 strain (A/duck/Alberta/35/76(H1N1) to be exact), had a similar effect.
Back to Swine flu. Swine flu is as old as the Spanish flu. After the outbreak of Spanish flu, pigs were reported to be having flu as well, a strong suggestion that the pigs got the flu from those who were infected by Spanish flu. Being pig, it was natural that the disease was called Swine flu.
On February 6, 1976, in the United States an army recruit at Fort Dix died, and four of his fellow soldiers were hospitalized. Like the 1918 pandemic, it was a variant of H1N1, called “A/New Jersey/1976 (H1N1)”. Luckily, it never spread out of Fort Dix.
Subsequent discoveries of various H1N1 strains were made at 1988 (United states), 1998 (United States), 2007 (Philippines), and eventually 2009 (everywhere).
In a way, the H1N1 thing the world is experiencing now, is a legacy of the 1918 Spanish flu. It was assumed that the virus most likely mutated and emerged from pigs in Asia, and it was carried to North America by infected people. Again, that’s how the flu outbreak was called “Swine flu”.
Fortunately for us, the strains we’re having is not as deadly as those in the Spanish flu outbreak. But it won’t stay that way forever. Just like how most of us are inclined to reproduce (having a baby) at some point in our life, viruses mutation is very likely too.
The only way I can think of to stop virus from mutating, is to stop it’s reproduction. If it can’t reproduce, it can’t mutate. To stop it from reproducing, we (human and animals) must stop getting infected. It sounds impossible, but the strain of Spanish flu did stopped reproducing itself, or at least I think so. Either that or the people of those time got lucky, that the particularly deadly H1N1 strain mutated into a non-lethal strain. Else we’ll still be dealing with a near-century long surviving deadly strain of H1N1.
So, do your part in saving the humankind, by avoiding crowded places unless it’s absolutely needed to go through them. After all, It took only one contact with an innocent looking monkey to cause havoc in the movie Outbreak (1995). Who knows if the stranger next to you might just do the same?
p/s: all references available at Wikipedia and your best friend, Google.

